RESEARCH GRANTS 

    • Project PNCD II nr. 41001/2007, Identification and characterization of brain cancer biomarkers expressed in serum and CSF through advanced glycomic methods based on mass spectrometry. (project webpage)
    • 2006-present, CEEX Module 3, 242/2006, "The development of a European Network for the investigation of interneuronal and neuroglial relations in energetic stress, neurodegenerative diseases and ageing, aiming the development of new therapeutic strategies". (project webpage)
    • 2004-2006, Viasan Project nr. 270/2004, National Research Programme VIASAN, „Study on the dorsal raphe 5-HT circuites on behavior and sleep. Neuropharmacological interactions with Nicotine”.
    • 2004-2006, Viasan Project nr. 269/2004, National Research Programme VIASAN, „Post-ischemic cortical hiperexcitabilitaty: in-vivo study on rat”.
    • 2003-2006, Viasan Project nr. 253/2003, National Research Programme VIASAN, „Cellular and molecular study of the effect of hypoxia on the in-vitro neuronal development and excitability ”.
    • 2001-2003, Viasan Project nr. 158/2001, National Research Programme VIASAN, „Molecular and cellular mecanisms of ischemic cerebral preconditioning”.

 

RESEARCH GRANTS WITH THE ROMANIAN ACADEMY OF MEDICAL SCIENCES 

    • EEG and Hypoxia in rat. 
    • Protective role of Gingko Biloba in cerebral ischemia in rat. 
    • 1994–1998, Project A14/1994, Contract nr. 85 /1994 between M.C.T. (A.N.S.T.I.) & UMF “Carol Davila”: „Protective effect of calcium blocking agents in cerebral ischemia.”. 
    • 1999–2000, Contract nr. 1285/1996, PROGRAM ORIZONT 2000 between A.N.S.T.I. & U.M.F. „Carol Davila”, through the following projects:
      • A10/1999, B10/2000 – „Study of the EEG computerised analysis of Kainic Acid induced experimental epilepsy”.
      • A11/1999, B11/2000 – „Preconditioning mechanisms in global cerebral ischemia and reperfusion”.
      • A8/1999, B8/2000 – „Cellular mechanisms induced by cerebral ischemia and reperfusion: Apoptosis, Necrosis, Neuronal survival”.
 


   RESEARCH PROJECTS IN DEVELOPMENT 
    • Cerebral ischemia/reperfusion and preconditioning in vivo and in vitro.
    • Kainate induced epilepsy in rat. 
    • NO and cerebral ischaemia in rat. 
    • Free radicals and cerebral ischaemia.
    • Sleep studies on human subjects concerning:
              - sleep architecture
              - study of dreams
              - study of memory
    • Sleep studies on rats
    • Memory, learning & behavior studies on rats
    • Cellular electrophysiology on brain slices and in-vivo brain in rats
    • Neuropharmacology studies
    • Ischemia/Hypoxia on neuron cell cultures 
       
 
  TECHNIQUES 
    • Four-vessel occlusion model for global cerebral ischaemia in rat.
    • Focal ischaemia by MCA occlusion.
    • Hypoxia induction model in rat. 
    • Stereotaxic drug administration. 
    • EEG recording and computerised EEG analysis in humans and in rats. 
    • Extra- and Intra-cellular electrophysiological recordings on brain slices and from in vivo rat brain.
    • In vivo and in vitro NO detection. 
    • Enzymatic determination on rat brain homogenate. 
    • Chronic electrophysiology electrodes implant. 
    • Polisomnographic recording and analisys in humans and in rats.
    • Neuronal cell cultures.
    • Ischemia/Hypoxia in vitro studies.
    • Immunohisto- and cyto-chemistry techniques.
    • Polimerase chain reaction.
    • Rat behavior and reaction tests